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Sigma
Angelicin
A0956
DOWNLOAD MSDS (PDF)Synonym: 2-
CAS Number: 523-50-2
Empirical Formula (Hill Notation): C11H6O3
Molecular Weight: 186.16
MDL number: MFCD00064930
PubChem Substance ID: 24890472
Properties
| Related Categories | AN-AZ, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, DNA Intercalators and Crosslinkers, |
| storage temp. | 2-8°C |
Description
Biochem/physiol Actions
Angular furocoumarin with diverse photobiological effects. Upon long-wavelength UV irradiation, forms monoadduct with double-stranded DNA and reacts with unsaturated fatty acids. Inhibits DNA and RNA synthesis and cell replication in Ehrlich ascites tumor cells.
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Safety Information
| Symbol |   GHS07, GHS08 |
| Signal word | Warning |
| Hazard statements | H302-H312-H315-H319-H332-H335-H351 |
| Precautionary statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38-40 |
| Safety Statements | 26-36/37/39 |
| WGK Germany | 3 |
| RTECS | LV0940000 |
Technical information & documentation associated with this product is available in the Safety & Documentation tab.
Articles
DNA Damage and Repair
Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
BioFiles 2007, 2.4, 20.
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Environmental, Gene expression, Metabolites, Methylations, Mutagens, Oxidations, PAGE, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription
References
Bordin, F., et al., Angelicins, angular analogs of psoralens: chemistry, photochemical, photobiological and phototherapeutic properties. Pharmacol. Ther. 52, 331-363, (1991)
Ebermann, R., et al., Natural products derived from plants as potential drugs for the photodynamic destruction of tumor cells. J. Photochem. Photobiol. B, Biol. 36, 95-97, (1996)
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